In situ expression of (R)-carbonyl reductase rebalancing an asymmetric pathway improves stereoconversion efficiency of racemic mixture to (S)-phenyl-1,2-ethanediol in Candida parapsilosis CCTCC M203011

BACKGROUND: Candida parapsilosis (R)-carbonyl reductase (RCR) and (S)-carbonyl reductase (SCR) are involved in the stereoconversion of racemic (R,S)-1-phenyl-1,2-ethanediol (PED) to its (S)-isomer. RCR catalyzes (R)-PED to 2-hydroxyacetophenone (2-HAP), and SCR catalyzes 2-HAP to (S)-PED. However, t...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Zhang, Rongzhen, Wang, Lei, Xu, Yan, Liang, Hongbo, Zhou, Xiaotian, Jiang, Jiawei, Li, Yaohui, Xiao, Rong, Ni, Ye
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989518/
https://ncbi.nlm.nih.gov/pubmed/27534936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0539-y
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