Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery

BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic stem cell transplantation (HSCT) promotes hematopoiesis by inducing HSC pr...

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書目詳細資料
發表在:J Hematol Oncol
Main Authors: Green, Michael M. B., Chao, Nelson, Chhabra, Saurabh, Corbet, Kelly, Gasparetto, Cristina, Horwitz, Ari, Li, Zhiguo, Venkata, Jagadish Kummetha, Long, Gwynn, Mims, Alice, Rizzieri, David, Sarantopoulos, Stefanie, Stuart, Robert, Sung, Anthony D., Sullivan, Keith M., Costa, Luciano, Horwitz, Mitchell, Kang, Yubin
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989381/
https://ncbi.nlm.nih.gov/pubmed/27535663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0301-2
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