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Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin signaling through the insulin receptor. The insulin receptor (INSR) exists as two isoforms, INSR-A and INSR-B, which results from...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Malakar, Pushkar, Chartarifsky, Lital, Hija, Ayat, Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval, Karni, Rotem
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985653/
https://ncbi.nlm.nih.gov/pubmed/27526875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31222
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