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Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin signaling through the insulin receptor. The insulin receptor (INSR) exists as two isoforms, INSR-A and INSR-B, which results from...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Malakar, Pushkar, Chartarifsky, Lital, Hija, Ayat, Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval, Karni, Rotem
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985653/
https://ncbi.nlm.nih.gov/pubmed/27526875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31222
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