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Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin signaling through the insulin receptor. The insulin receptor (INSR) exists as two isoforms, INSR-A and INSR-B, which results from...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Malakar, Pushkar, Chartarifsky, Lital, Hija, Ayat, Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval, Karni, Rotem
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985653/
https://ncbi.nlm.nih.gov/pubmed/27526875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31222
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