A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome

Low-grade chronic inflammation is a key etiological phenomenon responsible for the initiation and perpetuation of obesity and diabetes. Novel therapeutic approaches that can specifically target inflammatory pathways are needed to avert this looming epidemic of metabolic disorders. Genetic and chemic...

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Vydáno v:JCI Insight
Hlavní autoři: Srivastava, Neetu, Iyer, Sonia, Sudan, Raki, Youngs, Christie, Engelman, Robert W., Howard, Kyle T., Russo, Christopher M., Chisholm, John D., Kerr, William G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985248/
https://ncbi.nlm.nih.gov/pubmed/27536730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88544
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