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Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease

Vast evidence on human prions demonstrates that variable disease phenotypes, rates of propagation, and targeting of distinct brain structures are determined by unique conformers (strains) of pathogenic prion protein (PrP(Sc)). Recent progress in the development of advanced biophysical tools that inv...

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Publicat a:Prion
Autors principals: Cohen, Mark, Appleby, Brian, Safar, Jiri G.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981201/
https://ncbi.nlm.nih.gov/pubmed/26809345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2015.1123371
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