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Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon

We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 step...

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Détails bibliographiques
Publié dans:Front Chem
Auteurs principaux: Kolleth, Amandine, Gebauer, Julian, ElMarrouni, Abdelatif, Lebeuf, Raphael, Prévost, Céline, Brohan, Eric, Arseniyadis, Stellios, Cossy, Janine
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977289/
https://ncbi.nlm.nih.gov/pubmed/27556024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2016.00034
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