ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration

BACKGROUND: Colorectal cancer (CRC) is closely linked to Wnt signalling, with 94 % of cases exhibiting a Wnt related mutation. ROR2 is a receptor tyrosine kinase that is thought to repress β-catenin dependent Wnt signalling. Our study aims to determine if ROR2 is epigenetically silenced in CRC and d...

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Bibliografiska uppgifter
I publikationen:BMC Cancer
Huvudupphovsmän: Ma, Sean S. Q., Srivastava, Sameer, Llamosas, Estelle, Hawkins, Nicholas J., Hesson, Luke B., Ward, Robyn L., Ford, Caroline E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955198/
https://ncbi.nlm.nih.gov/pubmed/27440078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2576-7
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