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Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice
Lisofylline (LSF), is the R-(−) enantiomer of the metabolite M1 of pentoxifylline, and is currently under development for the treatment of type 1 diabetes. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model of LSF in mice and to perform simulations in order to p...
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| Veröffentlicht in: | Eur J Drug Metab Pharmacokinet |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer International Publishing
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4954844/ https://ncbi.nlm.nih.gov/pubmed/25663650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-015-0260-y |
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