Expression, purification and biological activity assessment of romiplostim biosimilar peptibody

BACKGROUND: Romiplostim is a peptibody analogue of thrombopoietin (TPO) which regulates platelet production. This molecule consists of two main parts: Peptide sequences which like wild type TPO, mimics stimulation of TPO receptor and IgG1Fc, (Peptide + Antibody = Peptibody). This drug is used in tre...

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Veröffentlicht in:Daru
Hauptverfasser: Fayaz, Shima, Fard-Esfahani, Pezhman, Golkar, Majid, Allahyari, Mojgan, Sadeghi, Sedigheh
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940717/
https://ncbi.nlm.nih.gov/pubmed/27401785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40199-016-0156-7
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