Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development; thus it may be anticipated that CSL deficiency should reduce tumor growth...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Braune, Eike-Benjamin, Tsoi, Yat Long, Phoon, Yee Peng, Landor, Sebastian, Silva Cascales, Helena, Ramsköld, Daniel, Deng, Qiaolin, Lindqvist, Arne, Lian, Xiaojun, Sahlgren, Cecilia, Jin, Shao-Bo, Lendahl, Urban
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939550/
https://ncbi.nlm.nih.gov/pubmed/27066863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.03.004
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