Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease

Staphylococcus aureus produces numerous virulence factors, each contributing different mechanisms to bacterial pathogenesis in a spectrum of diseases. Alpha toxin (AT), a cytolytic pore-forming toxin, plays a key role in skin and soft tissue infections and pneumonia, and a human anti-AT monoclonal a...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Tkaczyk, C., Hamilton, M. M., Sadowska, A., Shi, Y., Chang, C.S., Chowdhury, P., Buonapane, R., Xiao, X., Warrener, P., Mediavilla, J., Kreiswirth, B., Suzich, J., Stover, C. K., Sellman, B. R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937210/
https://ncbi.nlm.nih.gov/pubmed/27353753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00528-16
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