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Fabrication of water-soluble polymer-encapsulated As(4)S(4) to increase oral bioavailability and chemotherapeutic efficacy in AML mice
Realgar (As(4)S(4)) has been demonstrated to be effective for the treatment of acute myeloid leukemia (AML); it has the advantages of no drug resistance and oral administration. Nevertheless, its poor solubility has been an obstacle to its bioavailability, requiring high-dose administration over a l...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935940/ https://ncbi.nlm.nih.gov/pubmed/27383126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29348 |
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