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Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition

Long interspersed element type 1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome, encoding a newly identified ORF0 with unknown function, ORF1p with RNA-binding activity and ORF2p with endonuclease and reverse transcriptase activities required for L1 retrotransposit...

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Detalles Bibliográficos
Publicado en:Front Chem
Autor Principal: Ariumi, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924340/
https://ncbi.nlm.nih.gov/pubmed/27446907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2016.00028
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