A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation

10-Hydroxycamptothecin (10-HCPT) is a promising anticancer drug with a wide spectrum of antitumor activities. Due to its poor solubility, the carboxylate form that shows high water solubility but minimal anticancer activity and pharmacokinetic defects is used in the marketed 10-HCPT injections, resu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Nanomedicine
Main Authors: Yang, Xiaofeng, Liu, Yingying, Zhao, Yanna, Han, Meihua, Guo, Yifei, Kuang, Haixue, Wang, Xiangtao
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2016
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922823/
https://ncbi.nlm.nih.gov/pubmed/27382284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S102726
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