Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4(+) T cells through p65 and H2B phosphorylation

Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the permissive epigenetic landscape in memory T cells integrates incoming stimulatory signals remains poorly unde...

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Pubblicato in:J Cell Sci
Autori principali: Li, Jasmine, Hardy, Kristine, Phetsouphanh, Chan, Tu, Wen Juan, Sutcliffe, Elissa L., McCuaig, Robert, Sutton, Christopher R., Zafar, Anjum, Munier, C. Mee Ling, Zaunders, John J., Xu, Yin, Theodoratos, Angelo, Tan, Abel, Lim, Pek Siew, Knaute, Tobias, Masch, Antonia, Zerweck, Johannes, Brezar, Vedran, Milburn, Peter J., Dunn, Jenny, Casarotto, Marco G., Turner, Stephen J., Seddiki, Nabila, Kelleher, Anthony D., Rao, Sudha
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920249/
https://ncbi.nlm.nih.gov/pubmed/27149922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.181248
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