Synthesis, Formulation, and Adjuvanticity of Monodesmosidic Saponins with Olenanolic Acid, Hederagenin and Gypsogenin Aglycones, and some C‐28 Ester Derivatives

In an attempt to discover a new synthetic vaccine adjuvant, the glycosylation of hederagenin, gypsogenin, and oleanolic acid acceptors with di‐ and trisaccharide donors to generate a range of mimics of natural product QS‐21 was carried out. The saponins were formulated with phosphatidylcholine and c...

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Bibliographic Details
Published in:ChemistryOpen
Main Authors: Greatrex, Ben W., Daines, Alison M., Hook, Sarah, Lenz, Dirk H., McBurney, Warren, Rades, Thomas, Rendle, Phillip M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906508/
https://ncbi.nlm.nih.gov/pubmed/27308200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201500149
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