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BRAF inhibitors in colorectal cancer: Toward a differentiation therapy?
BRAF inhibitor monotherapy appears to be ineffective in BRAF(V600E)-positive colorectal cancer (CRC) as a result of inherent EGFR-mediated resistance mechanisms. This concept initiated combinatorial treatment approaches. Nevertheless, BRAF inhibition in isogenic CRC cell lines induced enhanced cell-...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905336/ https://ncbi.nlm.nih.gov/pubmed/27308494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2014.1002709 |
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