Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective antibodies. Antigen-activated B cells—with T-cell help—undergo affinity maturation within germinal centres and persist as long-lived IgG plasma cells in the bone marrow. Here we show that antigen-specific, in...

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Pubblicato in:Nat Commun
Autori principali: Bohannon, Caitlin, Powers, Ryan, Satyabhama, Lakshmipriyadarshini, Cui, Ang, Tipton, Christopher, Michaeli, Miri, Skountzou, Ioanna, Mittler, Robert S., Kleinstein, Steven H., Mehr, Ramit, Lee, Frances Eun-Yun, Sanz, Ignacio, Jacob, Joshy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899631/
https://ncbi.nlm.nih.gov/pubmed/27270306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11826
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