CD47 Blockade Reduces Ischemia Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model

BACKGROUND: Ischemia/reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation leading to graft loss. IRI is exacerbated by the thrombospondin-1/CD47 system through inhibition of nitric oxide signaling. We postulate that CD47 blockade and prevention of nitric oxid...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Lin, Yiing, Manning, Pamela T., Jia, Jianluo, Gaut, Joseph P., Xiao, Zhen-yu, Capoccia, Ben J., Chen, Chun-Cheng, Hiebsch, Ronald R., Upadhya, Gundumi, Mohanakumar, Thalachallour, Frazier, William A., Chapman, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887281/
https://ncbi.nlm.nih.gov/pubmed/24983310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000252
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