Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

The E3 small ubiquitin-like modifier (SUMO) protein ligase protein inhibitor of activated STAT 4 (PIAS4) is a pivotal protein in regulating the TGFβ pathway. In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulate...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Lear, Travis, McKelvey, Alison C., Rajbhandari, Shristi, Dunn, Sarah R., Coon, Tiffany A., Connelly, William, Zhao, Joe Y., Kass, Daniel J., Zhang, Yingze, Liu, Yuan, Chen, Bill B.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886359/
https://ncbi.nlm.nih.gov/pubmed/27162139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151229
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