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Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in Ca(V)1.1 calcium channels
Alternative splicing of the skeletal muscle Ca(V)1.1 voltage-gated calcium channel gives rise to two channel variants with very different gating properties. The currents of both channels activate slowly; however, insertion of exon 29 in the adult splice variant Ca(V)1.1a causes an ∼30-mV right shift...
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| Publié dans: | J Gen Physiol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4886277/ https://ncbi.nlm.nih.gov/pubmed/27185857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611568 |
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