Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in Ca(V)1.1 calcium channels

Alternative splicing of the skeletal muscle Ca(V)1.1 voltage-gated calcium channel gives rise to two channel variants with very different gating properties. The currents of both channels activate slowly; however, insertion of exon 29 in the adult splice variant Ca(V)1.1a causes an ∼30-mV right shift...

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Bibliographic Details
Published in:J Gen Physiol
Main Authors: Tuluc, Petronel, Benedetti, Bruno, Coste de Bagneaux, Pierre, Grabner, Manfred, Flucher, Bernhard E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886277/
https://ncbi.nlm.nih.gov/pubmed/27185857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611568
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