Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK

Metformin is a first-line drug for the management of type 2 diabetes. Recent studies suggested cardioprotective effects of metformin against ischemia/reperfusion injury. However, it remains elusive whether metformin provides direct protection against hypoxia/reoxygenation (H/R) injury in cardiomyocy...

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Bibliographic Details
Published in:J Diabetes Res
Main Authors: Hu, Mingyan, Ye, Ping, Liao, Hua, Chen, Manhua, Yang, Feiyan
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884853/
https://ncbi.nlm.nih.gov/pubmed/27294149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2961954
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