Arginase 1 is an innate lymphoid cell-intrinsic metabolic checkpoint controlling type 2 inflammation

Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair following activation by cell-extrinsic factors including host-derived cytokines. However, the cell-intrinsic metabolic pathways that control ILC2 function are undefined. Here we demonstrate that expression of the enzyme Ar...

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Publicado no:Nat Immunol
Main Authors: Monticelli, Laurel A, Buck, Michael D, Flamar, Anne-Laure, Saenz, Steven A, Wojno, Elia D Tait, Yudanin, Naomi A, Osborne, Lisa C, Hepworth, Matthew R, Tran, Sara V, Rodewald, Hans-Reimer, Shah, Hardik, Cross, Justin R, Diamond, Joshua M, Cantu, Edward, Christie, Jason D, Pearce, Erika L, Artis, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873382/
https://ncbi.nlm.nih.gov/pubmed/27043409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3421
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