Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8 T cell differentiation

The asymmetric partitioning of fate determining proteins has been shown to contribute to the generation of effector and memory CD8(+) T cell precursors. Here, we demonstrate the asymmetric partitioning of mTORC1 activity upon activation of naïve CD8(+) T cells. This results in the generation of one...

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Publicado en:Nat Immunol
Autores principales: Pollizzi, Kristen N., Sun, Im-Hong, Patel, Chirag H., Lo, Ying-Chun, Oh, Min-Hee, Waickman, Adam T., Tam, Ada J., Blosser, Richard L., Wen, Jiayu, Delgoffe, Greg M., Powell, Jonathan D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873361/
https://ncbi.nlm.nih.gov/pubmed/27064374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3438
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