Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection

Accumulation of somatic mutations in antibody variable regions is critical for antibody affinity maturation, with HIV-1 broadly neutralizing antibodies (bnAbs) generally requiring years to develop. We recently found that the rate at which mutations accumulate decreases over time, but the mechanism g...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Sheng, Zizhang, Schramm, Chaim A., Connors, Mark, Morris, Lynn, Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871536/
https://ncbi.nlm.nih.gov/pubmed/27191167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004940
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