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Structure–Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines on β-Amyloid Aggregation Kinetics
[Image: see text] A library of isomeric 2,4-diaminoquinazoline (DAQ) derivatives were synthesized and evaluated for antiaggregation potential toward Aβ40/42. Structure–activity relationship data identified compound 3k (N(4)-(4-bromobenzyl)quinazoline-2,4-diamine) with a 4-bromobenzyl substituent as...
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| Gepubliceerd in: | ACS Med Chem Lett |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2016
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867481/ https://ncbi.nlm.nih.gov/pubmed/27190601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00039 |
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