Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5/6 nephrectomy rat model

BACKGROUND: Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal EndoMT in chronic kidney disease by studying its effect in 5/6 nephrectomized...

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Bibliographic Details
Published in:BMC Nephrol
Main Authors: Bai, Jiuxu, Hao, Junfeng, Zhang, Xiaoling, Cui, Hanmin, Han, Jingming, Cao, Ning
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866282/
https://ncbi.nlm.nih.gov/pubmed/27176224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-016-0260-4
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