The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

The integrated stress response (ISR) is a homeostatic mechanism by which eukaryotic cells sense and respond to stress-inducing signals, such as amino acid starvation. General controlled nonrepressed (GCN2) kinase is a key orchestrator of the ISR, and modulates cellular metabolism in response to amin...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Ravindran, Rajesh, Loebbermann, Jens, Nakaya, Helder I, Khan, Nooruddin, Ma, Hualing, Gama, Leonardo, Machiah, Deepa K, Lawson, Benton, Hakimpour, Paul, Wang, Yi-chong, Li, Shuzhao, Sharma, Prachi, Kaufman, Randal J, Martinez, Jennifer, Pulendran, Bali
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854628/
https://ncbi.nlm.nih.gov/pubmed/26982722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17186
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