Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling

Metastasis is a complex process that is regulated by multiple signaling pathways, with the focal adhesion kinase (FAK)/paxillin pathway playing a major role in the formation of focal adhesions and cell motility. N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor in many soli...

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Publicado no:Mol Pharmacol
Main Authors: Wangpu, Xiongzhi, Lu, Jiaoyang, Xi, Ruxing, Yue, Fei, Sahni, Sumit, Park, Kyung Chan, Menezes, Sharleen, Huang, Michael L.H., Zheng, Minhua, Kovacevic, Zaklina, Richardson, Des R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851300/
https://ncbi.nlm.nih.gov/pubmed/26895766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.103044
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