Serine/Threonine kinase MLK4 determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent manner

Activation of NF-kB induces mesenchymal (MES) trans-differentiation and radio-resistance in glioma stem cells (GSCs), but molecular mechanisms for NF-kB activation in GSCs are currently unknown. Here we report that mixed lineage kinase 4 (MLK4) is overexpressed in MES but not proneural (PN) GSCs. Si...

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Publicado en:Cancer Cell
Main Authors: Kim, Sung-Hak, Ezhilarasan, Ravesanker, Phillips, Emma, Gallego-Perez, Daniel, Sparks, Amanda, Taylor, David, Ladner, Katherine, Furuta, Takuya, Sabit, Hemragul, Chhipa, Rishi, Cho, Ju Hwan, Mohyeldin, Ahmed, Beck, Samuel, Kurozumi, Kazuhiko, Kuroiwa, Toshihiko, Iwata, Ryoichi, Asai, Akio, Kim, Jonghwan, Sulman, Erik P., Cheng, Shiyuan, Lee, L.James, Nakada, Mitsutoshi, Guttridge, Denis, DasGupta, Biplab, Goidts, Violaine, Bhat, Krishna P., Nakano, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837946/
https://ncbi.nlm.nih.gov/pubmed/26859459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.01.005
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