Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model

SCOPE: Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is characterized by a spectrum of phenotypes including skeletal abnormalities. The Ts65Dn DS mouse model exhibits similar skeletal phenotypes as humans with DS. DYRK1A, a kinase encoded on Hsa21, has been linked to deficien...

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Pubblicato in:Mol Nutr Food Res
Autori principali: Abeysekera, Irushi, Thomas, Jared, Georgiadis, Taxiarchis M., Berman, Alycia G., Hammond, Max A., Dria, Karl J., Wallace, Joseph M., Roper, Randall J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828301/
https://ncbi.nlm.nih.gov/pubmed/26748562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201500781
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