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A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model
OBJECTIVE: The existing methods for identifying multiple rare variants underlying complex diseases in family samples are underpowered. Therefore, we aim to develop a new set-based method for an association study of dichotomous traits in family samples. METHODS: We introduce a framework for testing t...
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| Publicado en: | Hum Hered |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4825859/ https://ncbi.nlm.nih.gov/pubmed/25791389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000375409 |
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