A weakly acidic solution containing deoxycholic acid induces esophageal epithelial apoptosis and impairs integrity in an in vivo perfusion rabbit model

Impaired esophageal mucosal integrity may be an important contributor in the pathophysiology of gastroesophageal reflux disease (GERD). Nevertheless, the effect of potentially harmful agents on epithelial integrity is mainly evaluated in vitro for a short period of time and the possible induction of...

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Udgivet i:Am J Physiol Gastrointest Liver Physiol
Main Authors: Pardon, Nicolas A., Vicario, Maria, Vanheel, Hanne, Vanuytsel, Tim, Ceulemans, Laurens J., Vieth, Michael, Jimenez, Marcel, Tack, Jan, Farré, Ricard
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2016
Fag:
Translational Human Pathophysiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824175/
https://ncbi.nlm.nih.gov/pubmed/26797397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00370.2015
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