Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

Iron overload results in significant morbidity and mortality in β-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepcidin have therapeutic potential. We have previously shown that exogenous apo-transferrin markedly a...

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Publicat a:Haematologica
Autors principals: Chen, Huiyong, Choesang, Tenzin, Li, Huihui, Sun, Shuming, Pham, Petra, Bao, Weili, Feola, Maria, Westerman, Mark, Li, Guiyuan, Follenzi, Antonia, Blanc, Lionel, Rivella, Stefano, Fleming, Robert E., Ginzburg, Yelena Z.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815721/
https://ncbi.nlm.nih.gov/pubmed/26635037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.127902
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