Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination

Signal transduction from the T cell receptor (TCR) is crucial for T cell–mediated immune responses and, when deregulated, also contributes to the development of autoimmunity. How TCR signaling is regulated is incompletely understood. In this study, we demonstrate a ubiquitin-dependent mechanism in w...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Hu, Hongbo, Wang, Hui, Xiao, Yichuan, Jin, Jin, Chang, Jae-Hoon, Zou, Qiang, Xie, Xiaoping, Cheng, Xuhong, Sun, Shao-Cong
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813674/
https://ncbi.nlm.nih.gov/pubmed/26903241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151426
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