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Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
Signal transduction from the T cell receptor (TCR) is crucial for T cell–mediated immune responses and, when deregulated, also contributes to the development of autoimmunity. How TCR signaling is regulated is incompletely understood. In this study, we demonstrate a ubiquitin-dependent mechanism in w...
Gespeichert in:
| Veröffentlicht in: | J Exp Med |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813674/ https://ncbi.nlm.nih.gov/pubmed/26903241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151426 |
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