The High Degree of Sequence Plasticity of the Arenavirus Noncoding Intergenic Region (IGR) Enables the Use of a Nonviral Universal Synthetic IGR To Attenuate Arenaviruses

Hemorrhagic fever arenaviruses (HFAs) pose important public health problems in regions where they are endemic. Concerns about human-pathogenic arenaviruses are exacerbated because of the lack of FDA-licensed arenavirus vaccines and because current antiarenaviral therapy is limited to an off-label us...

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Udgivet i:J Virol
Main Authors: Iwasaki, Masaharu, Cubitt, Beatrice, Sullivan, Brian M., de la Torre, Juan C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810653/
https://ncbi.nlm.nih.gov/pubmed/26739049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03145-15
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