Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing

Next-generation sequencing (NGS) technology has shown promise for the detection of human pathogens from clinical samples. However, one of the major obstacles to the use of NGS in diagnostic microbiology is the low ratio of pathogen DNA to human DNA in most clinical specimens. In this study, we aimed...

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書目詳細資料
發表在:J Clin Microbiol
Main Authors: Hasan, Mohammad R., Rawat, Arun, Tang, Patrick, Jithesh, Puthen V., Thomas, Eva, Tan, Rusung, Tilley, Peter
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2016
主題:
Bacteriology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809942/
https://ncbi.nlm.nih.gov/pubmed/26763966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.03050-15
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