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Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing

Next-generation sequencing (NGS) technology has shown promise for the detection of human pathogens from clinical samples. However, one of the major obstacles to the use of NGS in diagnostic microbiology is the low ratio of pathogen DNA to human DNA in most clinical specimens. In this study, we aimed...

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Библиографические подробности
Опубликовано в: :J Clin Microbiol
Главные авторы: Hasan, Mohammad R., Rawat, Arun, Tang, Patrick, Jithesh, Puthen V., Thomas, Eva, Tan, Rusung, Tilley, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809942/
https://ncbi.nlm.nih.gov/pubmed/26763966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.03050-15
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