Cytotoxic T cells use mechanical force to potentiate target cell killing

The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected or transformed target cell is a physically active structure capable of exerting mechanical force. Here, we investigated whether synaptic forces promote the destruction of target cells. CTLs kill by secreting toxi...

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Udgivet i:Cell
Main Authors: Basu, Roshni, Whitlock, Benjamin M., Husson, Julien, Le Floc’h, Audrey, Jin, Weiyang, Oyler-Yaniv, Alon, Dotiwala, Farokh, Giannone, Gregory, Hivroz, Claire, Biais, Nicolas, Lieberman, Judy, Kam, Lance C., Huse, Morgan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808403/
https://ncbi.nlm.nih.gov/pubmed/26924577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.021
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