Neutralization of pro‐inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis

Monocytes have emerged as critical driving force of acute inflammation. Here, we show that inhibition of Toll‐like receptor 2(TLR2) dimerization by a TLR2 transmembrane peptide (TLR2‐p) ameliorated DSS‐induced colitis by interfering specifically with the activation of Ly6C(+) monocytes without affec...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Shmuel‐Galia, Liraz, Aychek, Tegest, Fink, Avner, Porat, Ziv, Zarmi, Batya, Bernshtein, Biana, Brenner, Ori, Jung, Steffen, Shai, Yechiel
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801944/
https://ncbi.nlm.nih.gov/pubmed/26884587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592649
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