Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

BACKGROUND: The metabolism of cancer cells is often reprogrammed by dysregulation of metabolic enzymes. Transketolase-like 1 (TKTL1) is a homodimeric transketolase linking the pentose-phosphate pathway with the glycolytic pathway. It is generally silenced at a transcriptional level in somatic tissue...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Jayachandran, Aparna, Lo, Pu-Han, Chueh, Anderly C., Prithviraj, Prashanth, Molania, Ramyar, Davalos-Salas, Mercedes, Anaka, Matthew, Walkiewicz, Marzena, Cebon, Jonathan, Behren, Andreas
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763451/
https://ncbi.nlm.nih.gov/pubmed/26907172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2185-5
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