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Evaluating 5-Nitrothiazoles as Trypanocidal Agents

The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expressi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: O'Shea, Ivan P., Shahed, Mohammed, Aguilera-Venegas, Benjamín, Wilkinson, Shane R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750693/
https://ncbi.nlm.nih.gov/pubmed/26596950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02006-15
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