Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA Associations

To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide polymorphisms (SNPs) in 532 LOMG cases (anti–acetylcholine receptor [AChR] antibody positive; onset age ≥50 years) and 2,128 controls matched...

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Foilsithe in:Mol Med
Main Authors: Seldin, Michael F, Alkhairy, Omar K, Lee, Annette T, Lamb, Janine A, Sussman, Jon, Pirskanen-Matell, Ritva, Piehl, Fredrik, Verschuuren, Jan J G M, Kostera-Pruszczyk, Anna, Szczudlik, Piotr, McKee, David, Maniaol, Angelina H, Harbo, Hanne F, Lie, Benedicte A, Melms, Arthur, Garchon, Henri-Jean, Willcox, Nicholas, Gregersen, Peter K, Hammarstrom, Lennart
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Feinstein Institute Press 2015
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749491/
https://ncbi.nlm.nih.gov/pubmed/26562150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00232
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