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Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride

OBJECTIVES: The study aims at applying pharmaceutical nanotechnology and D-optimal fractional factorial design to screen and optimize the high-risk variables affecting the performance of a complex drug delivery system consisting of glimepiride–Zein nanoparticles and inclusion of the optimized formul...

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Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Ahmed, Osama Abdelhakim Aly, Zidan, Ahmed Samir, Khayat, Maan
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745829/
https://ncbi.nlm.nih.gov/pubmed/26893561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S99731
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