TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases

NF-κB activation depends on the IKK complex consisting of the catalytically active IKK1 and 2 subunits and the scaffold protein NEMO. Hitherto, IKK2 activation has always been associated with IκBα degradation, NF-κB activation, and cytokine production. In contrast, we found that in SCF-stimulated pr...

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Udgivet i:Oncotarget
Main Authors: Drube, Sebastian, Weber, Franziska, Göpfert, Christiane, Loschinski, Romy, Rothe, Mandy, Boelke, Franziska, Diamanti, Michaela A., Löhn, Tobias, Ruth, Julia, Schütz, Dagmar, Häfner, Norman, Greten, Florian R., Stumm, Ralf, Hartmann, Karin, Krämer, Oliver H., Dudeck, Anne, Kamradt, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745695/
https://ncbi.nlm.nih.gov/pubmed/26353931
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