CD8(+) T cells undergo activation and programmed death-1 repression in the liver of aged Ae2(a,b)(−/−) mice favoring autoimmune cholangitis

Primary biliary cirrhosis (PBC) is a chronic cholestatic disease of unknown etiopathogenesis showing progressive autoimmune-mediated cholangitis. In PBC patients, the liver and lymphocytes exhibit diminished expression of AE2/SLC4A2, a Cl(−)/HCO(3)(−) anion exchanger involved in biliary bicarbonate...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Concepcion, Axel R., Salas, January T., Sáez, Elena, Sarvide, Sarai, Ferrer, Alex, Portu, Ainhoa, Uriarte, Iker, Hervás-Stubbs, Sandra, Oude Elferink, Ronald P.J., Prieto, Jesús, Medina, Juan F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
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Research Paper: Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745679/
https://ncbi.nlm.nih.gov/pubmed/26396175
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